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KMID : 0371019970300010001
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Journal of Preventive Medicine and Public Health
1997 Volume.30 No. 1 p.1 ~ p.16
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A Case-Control Study on Association Between Hepatocellular Carcinoma and Infection of Hepatitis B and Hepatitis C Virus
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Kim Min-Ho
Ahn Hyeong-Sik
Kim Young-Sik
Kim Jung-Soon
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Abstract
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To investigate association between hepatocellular carcinoma(HCC) and infection of hepatitis B virus(HBV) and hepatitis C virus(HCV) in an -HBV endemic area, a case-control study of 254 patients with HCC and of 1,270 age and sex matched health control subjects was done. Among the 254 HCC patients 166(65.44%) were positive for hepatitis B surface antigen(HBsAg), 49(19.3%) were positive for HCV antibody (anti-HCV Ab). The crude odd ratio of patients with HBsAg wasl"36.1(95% CI :22.4-58. 2) and with anti-HCV Ab was 9.0(95% CI :5.5-14.6). In an analysis, which HBsAg(-), HBcAb(-), anti-HCV Ab(-) group was chosen as referent group, odd ratio of HBsAg(+) group was 14.4(95% CI: 7.2-28.9) and of anti- HCV Ab(+) was 10.7(95% CI: 2.9-40.0). Odd ratio of anti-HCV Ab(+), HBsAg(+) group and anti-HCV Ab(+), HBsAg(-), HBcAb(+) group for HCC were elevated to 27.3(95% CI : 9.0-$2.9) , 15.9(95% CI:7. 1-35.8) respectly. The odd ratio of anti-HCV Ab(-), HBsAg(-), -IBcAb(+) group was 2.4(95% CI : 1.1-5.0).
These result suggested that HBV and HCV were associated With HCC. In HBV endemic area patients with HBcAb alone should be considered risk group for HCC.
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KEYWORD
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Hepatocellular carcinoma, Odd ratio, Hepatitis B surface antigen, Hepatitis B core antibody, Hepatitis C antibody
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